Abstract #2091
Propofol-Induced Reduction of Functional Connectivity in Large-Scale Brain Networks Defined at Fine Spatial Scales
Xiaolin Liu 1 , Kathryn K. Lauer 2 , B. Douglas Ward 1 , Jeffrey R. Binder 3 , Shi-Jiang Li 1 , and Anthony G. Hudetz 2
1
Biophysics, Medical College of Wisconsin,
Milwaukee, Wisconsin, United States,
2
Anesthesiology,
Medical College of Wisconsin, Milwaukee, Wisconsin,
United States,
3
Neurology,
Medical College of Wisconsin, Milwaukee, Wisconsin,
United States
We proposed a neuroimaging-based anatomical-functional
parcellation algorithm for defining brain networks at
arbitrary spatial scales and extended this approach to
determine global changes in brain functional
connectivity during propofol sedation at two sedation
levels as compared to wakeful baseline and recovery.
Propofol sedation and its deepening are associated with
a global reduction of brain functional connectivity.
Reduced node connectivity in deep sedation showed
different degrees of involvement of cortical and
subcortical systems. The study represents a way of
comprehensively characterizing complex functional and
behavioral changes in sensory, attentional, cognitive
and motor systems of the brain during anesthetic
sedation.
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