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Abstract #2093

Magnetic vestibular stimulation (MVS) influences fMRI resting-state fluctuations: The modulation of the default-mode network as an exemplary case

Rainer Boegle 1,2 , Thomas Stephan 1,3 , Matthias Ertl 2,3 , Stefan Glasauer 1,4 , and Marianne Dieterich 1,3

1 German Center for Vertigo and Balance Disorders, DSGZ IFB-LMU, Munich, Bavaria, Germany, 2 Graduate School of Systemic Neurosciences, LMU, Munich, Bavaria, Germany, 3 Department of Neurology, LMU, Munich, Bavaria, Germany, 4 Center for Sensorimotor Research, LMU, Munich, Bavaria, Germany

Recently it was demonstrated that healthy subjects inside MR machines develop a persistent nystagmus in darkness, while patients who are lacking bilateral peripheral vestibular function do not. We studied the influence of this magnetic vestibular stimulation (MVS) on fMRI resting-state fluctuations in healthy subjects, at 1.5Tesla and at 3Tesla. We found that significant modulation of the default mode network occurs, mainly in areas associated with vestibular function. As proposed for MVS, the modulation-scaling is significantly higher than the expected BOLD signal increase due to B0 without an additional modulation effect. We conclude that MVS does significantly modulate fMRI resting-state networks.

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