Abstract #2094
Inter-hemispheric connectivity (functional homotopy) is reduced in pediatric epileptic patients with corpus callosotomy
Peter S LaViolette 1 , Sean Lew 2 , Scott D Rand 1 , Manoj Raghavan 3 , Kurt Hecox 3 , and Mohit Maheshwari 1
1
Radiology, Medical College of Wisconsin,
Milwaukee, WI, United States,
2
Neurosurgery,
Medical College of Wisconsin, Milwaukee, WI, United
States,
3
Neurology,
Medical College of Wisconsin, Milwaukee, WI, United
States
Interhemispheric functional connectivity can be modeled
with a new technique called functional homotopy. We
acquired resting-state fMRI (rs-fMRI) in two pediatric
patients following corpus callosotomy (severing the
corpus callosum) for treatment of refractory epilepsy.
We calculated homotopy and compared their data to a
control dataset to determine differences. We find global
changes in interhemispheris connectivity due to the
severing of the corpus callosum.
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