Abstract #2109
Metabolic basis for the "rest" condition in fMRI: Comparison of eyes open vs. closed states reveals constancy of glucose metabolism across networks
Garth John Thompson 1 , Valentin Riedl 2,3 , Timo Grimmer 3,4 , Alexander Drzezga 5 , Peter Herman 1 , and Fahmeed Hyder 1,6
1
Diagnostic Radiology, Magnetic Resonance
Research Center, Yale University, New Haven, CT, United
States,
2
Neuroradiology,
Nuclear Medicine, Universitt Mnchen, Mnchen, Germany,
3
Technische,
Universitt Mnchen - Neuroimaging Center, Mnchen,
Germany,
4
Psychiatry,
Universitt Mnchen, Mnchen, Germany,
5
Nuclear
Medicine, Uniklinikum, Koeln, Germany,
6
Biomedical
Engineering, Yale University, New Haven, CT, United
States
While resting-state fMRI (R-fMRI) is powerful, specific
"rest" condition parameters (e.g., eyes closed vs. open)
vary study to study. Subjects underwent simultaneous
R-fMRI and PET scans with eyes open and closed. R-fMRI
data were used to generate networks, whereas PET data
mapped glucose consumption (CMR
glc
). While
globally higher CMR
glc
was
observed with eyes open, there were insignificant CMR
glc
differences
across networks for either state. Since all R-fMRI
networks were detected regardless of the state, CMR
glc
constancy
across networks for a state suggests that the brain
easily transitions between these networks and either
"rest" condition can be used for R-fMRI.
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