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Abstract #2109

Metabolic basis for the "rest" condition in fMRI: Comparison of eyes open vs. closed states reveals constancy of glucose metabolism across networks

Garth John Thompson 1 , Valentin Riedl 2,3 , Timo Grimmer 3,4 , Alexander Drzezga 5 , Peter Herman 1 , and Fahmeed Hyder 1,6

1 Diagnostic Radiology, Magnetic Resonance Research Center, Yale University, New Haven, CT, United States, 2 Neuroradiology, Nuclear Medicine, Universitt Mnchen, Mnchen, Germany, 3 Technische, Universitt Mnchen - Neuroimaging Center, Mnchen, Germany, 4 Psychiatry, Universitt Mnchen, Mnchen, Germany, 5 Nuclear Medicine, Uniklinikum, Koeln, Germany, 6 Biomedical Engineering, Yale University, New Haven, CT, United States

While resting-state fMRI (R-fMRI) is powerful, specific "rest" condition parameters (e.g., eyes closed vs. open) vary study to study. Subjects underwent simultaneous R-fMRI and PET scans with eyes open and closed. R-fMRI data were used to generate networks, whereas PET data mapped glucose consumption (CMR glc ). While globally higher CMR glc was observed with eyes open, there were insignificant CMR glc differences across networks for either state. Since all R-fMRI networks were detected regardless of the state, CMR glc constancy across networks for a state suggests that the brain easily transitions between these networks and either "rest" condition can be used for R-fMRI.

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