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Abstract #2110

Simultaneous acquisition of structural and resting state functional connectivity data using a volumetric navigated diffusion sequence

Mwape Mofya 1 , Alkatafi Ali Alhamud 1 , Paul A. Taylor 1,2 , Andr J. W. van der Kouwe 3 , and Ernesta M. Meintjes 1

1 MRC/UCT Medical Imaging Research Unit, Department of Human Biology, University of Cape Town, Cape Town, South Africa, 2 African Institute for Mathematical Sciences (AIMS), South Africa, 3 Massachusetts General Hospital, Boston, Massachusetts, United States

Simultaneous DTI-fMRI data collection has previously been unsuccessful, due to mutual interference of the acquired DTI and fMRI signals. In this work, a single 3D EPI navigator, which has been used for motion correction and shown not to interfere with DWI collection, has been inserted after each DWI volume for BOLD measurement. For faster temporal sampling, we also test the inclusion of a second 3D EPI navigator in the middle of each DTI volume acquisition. Resting state networks produced in the standard BOLD and double navigated DTI-fMRI showed quite similar spatial extent and connectivity. Diffusion data produced similar whole brain distributions of tensor parameters, as well as strikingly similar tractographic reconstructions.

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