Local intrinsic connectivity measures relate to GABA/Glx levels
Katarzyna Bienkowska 1 and Valentin Riedl 1
Neuroradiology, Technische Universitat
Munchen, Munich, Germany
In presented study, a combined fMRI-MRS study has been
performed to examine interactions between GABA/Glx
levels and local intrinsic brain activity (iFC).
Recently there has been considerable progress done in
investigating interactions between GABA level and BOLD
signal change during visual stimulation. What has not
been carefully studied yet is the relationship between
resting state coherent BOLD signal change (functional
connectivity) and excitatory/inhibitory neurotransmitter
balance. Therefore, GABA and Glx concentration in the
occipital cortex were correlated with local functional
connectivity (lFC) and amplitude of low frequency
fluctuations (ALFF) of the resting brain in eyes-open
and eyes-closed condition.
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