Abstract #2114
Micro- and macrovascular contributions to layer-dependent blood volume fMRI: a multi-modal, multi-species comparison
Laurentius Huber 1 , Jozien Goense 2 , Aneurin Kennerley 3 , Maria Guidi 1 , Robert Trampel 1 , Robert Turner 1 , and Harald E Mller 1
1
Max Planck Institute for Human Cognitive &
Brain Sciences, Leipzig, Germany,
2
University
of Glasgow, United Kingdom,
3
University
of Sheffield, United Kingdom
This study investigates cortical layer-dependent
functional changes of cerebral blood volume (
CBV
)
in humans, monkeys and rats at 7 T. Using multiple
imaging modalities including vascular space occupancy
(VASO), iron-oxide contrast agent based fMRI, and
optical imaging spectroscopy, we investigated the
contributions of pial macrovasculature and
layer-specific microvasculature to
CBV
based
fMRI signals. Based on the results presented here, we
suggest that the pial macrovasculature can introduce
amplifying or attenuating signal contributions to
layer-dependent
CBV
responses.
These contaminations manifest themselves differently,
depending on the units (ml or %) used in the evaluation
procedure.
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