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Abstract #2114

Micro- and macrovascular contributions to layer-dependent blood volume fMRI: a multi-modal, multi-species comparison

Laurentius Huber 1 , Jozien Goense 2 , Aneurin Kennerley 3 , Maria Guidi 1 , Robert Trampel 1 , Robert Turner 1 , and Harald E Mller 1

1 Max Planck Institute for Human Cognitive & Brain Sciences, Leipzig, Germany, 2 University of Glasgow, United Kingdom, 3 University of Sheffield, United Kingdom

This study investigates cortical layer-dependent functional changes of cerebral blood volume ( CBV ) in humans, monkeys and rats at 7 T. Using multiple imaging modalities including vascular space occupancy (VASO), iron-oxide contrast agent based fMRI, and optical imaging spectroscopy, we investigated the contributions of pial macrovasculature and layer-specific microvasculature to CBV based fMRI signals. Based on the results presented here, we suggest that the pial macrovasculature can introduce amplifying or attenuating signal contributions to layer-dependent CBV responses. These contaminations manifest themselves differently, depending on the units (ml or %) used in the evaluation procedure.

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