Differences in the resting-state fMRI global signal amplitude between the eyes open and eyes closed states are related to changes in EEG vigilance

The amplitude of the resting-state fMRI global signal was compared between eyes open (EO) and eyes closed (EC) states. The amplitude of the global signal was significantly lower in the EO state and the magnitude of the decrease was correlated with increases in EEG vigilance. The relation between the EO-EC changes in global signal amplitude and EEG vigilance was found to be similar to that previously observed for caffeine-related changes in global signal amplitude and vigilance.

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