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Abstract #2117

Map the light-driven fMRI signal in combination with in vivo recording

Maosen Wang 1 , Yi He 1 , Yaohui Tang 1 , Dvid Zsolt Balla 2 , Chunqi Qian 3 , and Xin Yu 1

1 Research Group of Translational Neuroimaging and Neural Conteol,High Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tuebingen, Baden-Wuerttemberg, Germany, 2 Department of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Tuebingen, Baden-Wuerttemberg, Germany, 3 Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Str, National Institutes of Health, Bethesda, MD, United States

It remains ambiguous how the direct fiber optic insertion affects the local fMRI signal by optical stimulation. The fiber optic was inserted to target the deep layer cortex expressing Channelrhodopsin 2(ChR2). Robust fMRI signal was detected in the cortical regions close to the fiber tip with varied light pulse parameters on frequency, pulse duration and power level. The light evoked local field potential was also recorded by electrodes inserted into the cortex expressing ChR2. This work provides us a robust light-driven fMRI platform in combination with in vivo recording, which will facilitate the study to decipher cellular contribution to fMRI signal from the local neurovascular network.

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