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Abstract #2118

Investigating the role of interictal activity during a natural stimulus presentation in children with epilepsy

Elhum A Shamshiri 1 , Maria Centeno 1 , Tim Tierney 1 , Kelly St Pier 2 , Ronit Pressler 2 , Suejen Perani 1,3 , Helen J Cross 4 , and David W Carmichael 1

1 Developmental Imaging and Biophysics Section, UCL Institute of Child Health, London, United Kingdom, 2 Epilepsy Unit, Great Ormond Street Hospital, London, United Kingdom, 3 Department of Basic and Clinical Neurosciences, Institute of Psychiatry, Psychology, and neuroscience, London, United Kingdom, 4 Neurosciences Unit, University College London, London, United Kingdom

Previously, cognitive network aberrations have been shown in epilepsy patients with regards to resting state networks such as the DMN (default mode network). However, the influence of interictal activity on these networks has yet to be properly explored. This study uses EEG-fMRI to explore the effect of spikes as a regressor of no interest in cognitive networks using a general linear model (GLM) and functional connectivity.

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