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Abstract #2128

Physiological Modulators of Resting-State MRI Functional Connectivity

Powell Pui Wai Chu 1,2 , Ali M. Golestani 1 , Jonathan B. Kwinta 1,2 , Yasha B. Khatamian 1 , and Jean J. Chen 1,2

1 Rotman Research Institute, Baycrest, Toronto, Ontario, Canada, 2 Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

Resting-state fMRI functional connectivity (rs-fcMRI) measurements are based on the BOLD fMRI signal, which is influenced by systemic physiological variability. Thus, fcMRI data interpretation may be difficult across different subjects without the knowledge of these physiological influences. In this work, in order to improve the reliability of rs-fcMRI measurements, we assess the influence of physiological factors including baseline cerebral blood flow and venous blood oxygenation on functional connectivity estimates. We found a significance relationship between rs-fcMRI values and the above two physiological variables.

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