Investigation of neurovascular coupling within brain by simultaneous recordings of LFP and fiber-optic hemodynamic signals

Intrinsic optical spectroscopy (IOS) may provide multiple hemodynamic parameters in high time resolution in functional optical imaging but rarely used within brain study. We developed a combination of optic fiber-based IOS, ~100um in diameter, and microelectrode neuronal LFP signal recording within brain at similar spatial range, a few hundred micros. This simultaneous recording design may be a promising approach for examining target sites of neurovascular coupling relations in brain.

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