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Abstract #2136

Investigation of neurovascular coupling within brain by simultaneous recordings of LFP and fiber-optic hemodynamic signals

Wen-Ju Pan 1 , Jacob Billings 1 , and Shella Keilholz 1

1 Biomedical Engineering, Emory University/ Georgia Institute of Technology, Atlanta, Georgia, United States

Intrinsic optical spectroscopy (IOS) may provide multiple hemodynamic parameters in high time resolution in functional optical imaging but rarely used within brain study. We developed a combination of optic fiber-based IOS, ~100um in diameter, and microelectrode neuronal LFP signal recording within brain at similar spatial range, a few hundred micros. This simultaneous recording design may be a promising approach for examining target sites of neurovascular coupling relations in brain.

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