Simultaneous Voxel-wise Mapping of Oxygen Extraction Fraction, Blood Flow and Cerebral Metabolic Rate of Oxygen

An integrated MRI protocol was developed for simultaneous mapping of CBF with acceleration-based ASL and OEF with GESFIDE. The GESFIDE module was integrated into the post-label delay control module of the ASL sequence and total scan time was 405sec. Preliminary results in eight subjects, after averaging of data across the brain and subjects yielded values of 47.74.8mL/100g/min, 32.72.6%, and 123.811.1mol/100g/min for CBF, OEF and CMRO2, respectively, in good agreement with the literature. Positive correlations between CBF and CMRO2 and negative trend between CBF and OEF were found. Global CMRO2 value correlated significantly with other established methods for the same subjects.

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