Simultaneous Voxel-wise Mapping of Oxygen Extraction Fraction, Blood Flow and Cerebral Metabolic Rate of Oxygen
Yongxia Zhou 1 , Zachary B Rodgers 1 , and Felix W Wehrli 1
Radiology, University of Pennsylvania,
Philadelphia, Pennsylvania, United States
An integrated MRI protocol was developed for
simultaneous mapping of CBF with acceleration-based ASL
and OEF with GESFIDE. The GESFIDE module was integrated
into the post-label delay control module of the ASL
sequence and total scan time was 405sec. Preliminary
results in eight subjects, after averaging of data
across the brain and subjects yielded values of
47.74.8mL/100g/min, 32.72.6%, and
123.811.1mol/100g/min for CBF, OEF and CMRO2,
respectively, in good agreement with the literature.
Positive correlations between CBF and CMRO2 and negative
trend between CBF and OEF were found. Global CMRO2 value
correlated significantly with other established methods
for the same subjects.
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