Time-Dependent Influence of Hypoxic Ischemic Encephalopathy in Cerebral Metabolite Changes in Neonatal Rats Detected by In vivo 1H MR Spectroscopy at 9.4 T
Do-Wan Lee 1,2 , Dong-Cheol Woo 2 , Minyoung Lee 2,3 , Chul-Woong Woo 2 , Sang-Tae Kim 2 , Choong Gon Choi 4 , Bo-Young Choe 1 , and Byong Sop Lee 3
Department of Biomedical Engineering, and
Research Institute of Biomedical Engineering, The
Catholic University of Korea College of Medicine, Seoul,
Institute for Life Sciences, Asan Medical Center, Seoul,
of Pediatrics, Asan Medical Center, University of Ulsan
College of Medicine, Seoul, Korea,
of Radiology, Asan Medical Center, University of Ulsan
College of Medicine, Seoul, Korea
The purpose of this study was to quantitatively
determine the influence of the time-dependent effects of
hypoxic-ischemic-encephalopathy (HIE) on cerebral
metabolite changes in a neonatal rat model of severe HIE.
Our results exhibited that a total of 16 metabolite
signals in HIE rats were significantly altered with
increased periods of development (at PD7, PD14, and
PD28), compared to the CNTL. The present study is unique
in that we discovered not only the usefulness of
traditional markers (NAA, Cr, and choline-containing-compounds)
but also several new results (Ala, Asp, Glu, Gln, and
GSH, etc.) from a neonatal rat model of severe HIE.
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