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Abstract #2141

Marked perturbations in CBF and CO2 reactivity in subarachnoid hemorrhage

Yuhao Sun 1,2 , Qiang Shen 1 , Shiliang Huang 1 , and Timothy Q. Duong 1

1 Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States, 2 Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Subarachnoid hemorrhage (SAH) is a medical emergency. Vasospasm is widely reported. However, its effects on cerebral blood flow (CBF) and cerebrovascular reactivity are seldom studied. We found SAH induced marked perturbations of basal CBF and cerebrovascular reactivity in an established animal of SAH from day 0 to 7. CBF and cerebrovascular reactivity recovered gradually by day 7. This study investigated the effects of SAH on CBF and CO2 reactivity in an established rat model. We concluded that hemodynamic disturbance in the brain after subarachnoid hemorrhage could contribute to progressive neurological deficits.

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