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Abstract #2142

Chronic cerebral hypoperfusion induces cerebral hemodynamics and angiogenesis

Shi Chang-Zheng 1 , Jing Zhen 1 , Ruan Yiwen 1 , and Huang Lian 1

1 Jinan University, Guangzhou, Guangdong, China

Most pathological changes were elicited when BCCAO was induced simultaneously at both the left and right CCAs. Another model was later introduced where BCCAO was induced with one week interval between the first and second CCA occlusions . The latter allows gradual development of CCH within the brain. Although the pathological mechanisms of these models have been widely studied, dynamic changes in CBF and angiogenesis are not completely understood.

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