Chronic cerebral hypoperfusion induces cerebral hemodynamics and angiogenesis
Shi Chang-Zheng 1 , Jing Zhen 1 , Ruan Yiwen 1 , and Huang Lian 1
Jinan University, Guangzhou, Guangdong,
Most pathological changes were elicited when BCCAO was
induced simultaneously at both the left and right CCAs.
Another model was later introduced where BCCAO was
induced with one week interval between the first and
second CCA occlusions . The latter allows gradual
development of CCH within the brain. Although the
pathological mechanisms of these models have been widely
studied, dynamic changes in CBF and angiogenesis are not
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