Time-to-Peak of T2*-Weighted Signal Change of Oxygen Challenge Improves the Identification of Penumbra in Ischemic Stroke

Percent change of T2*-weighted signal following oxygen challenge (OC) has been used as a biomarker of penumbra. However, T2*-weighted MRI of OC challenge in delineating tissue at risk has low contrast-to-noise sensitivity and there are significant false positive and negative pixels, particular from pixels that contain large vessels. In order for this biomarker to be practical, it is necessary to improve its specificity and sensitivity. The goal of this study was to explore the use of the time-to-peak of OC response to further improve the identification of at-risk tissue in ischemic stroke.

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