Abstract #2144
Diffusion-weighted Spatiotemporal Encoding Schemes in the Assessment of SPIO-labeled Cell Therapy for Ischemic Stroke
Jens T Rosenberg 1,2 , Avigdor Leftin 3 , Eddy Soloman 3 , Lucio Frydman 1,3 , and Samuel C Grant 1,2
1
National High Magnetic Field Laboratory,
Florida State University, Tallahassee, FL, United
States,
2
Chemical
& Biomedical Engineering, Florida State University,
Tallahassee, FL, United States,
3
Chemical
Physics, Weizmann Institute of Science, Rehovot, Israel
Diffusion-weighted spatiotemporal encoding (DW-SPEN) was
used to evaluate a pre-clinical in vivo model of
ischemic stroke under treatment with super-paramagnetic
iron-oxide labeled human mesenchymal stem cells at 21.1
T. In the presence of the induced background
susceptibility gradient, this work demonstrates more
robust quantification of in vivo diffusion parameters in
DW-SPEN to DW-EPI and DW spin-echo acquisition methods.
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