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Abstract #2144

Diffusion-weighted Spatiotemporal Encoding Schemes in the Assessment of SPIO-labeled Cell Therapy for Ischemic Stroke

Jens T Rosenberg 1,2 , Avigdor Leftin 3 , Eddy Soloman 3 , Lucio Frydman 1,3 , and Samuel C Grant 1,2

1 National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, United States, 2 Chemical & Biomedical Engineering, Florida State University, Tallahassee, FL, United States, 3 Chemical Physics, Weizmann Institute of Science, Rehovot, Israel

Diffusion-weighted spatiotemporal encoding (DW-SPEN) was used to evaluate a pre-clinical in vivo model of ischemic stroke under treatment with super-paramagnetic iron-oxide labeled human mesenchymal stem cells at 21.1 T. In the presence of the induced background susceptibility gradient, this work demonstrates more robust quantification of in vivo diffusion parameters in DW-SPEN to DW-EPI and DW spin-echo acquisition methods.

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