Abstract #2150
Absolute T 1 and T 2 Relaxation Times; Proxies for Onset Time and Tissue Status Assessment in Acute Ischaemic Stroke
Harriet J Rogers 1 , Bryony L McGarry 1 , Kimmo T Jokivarsi 2 , Michael J Knight 1 , Alejandra Sierra Lopez 2 , Olli HJ Grhn 2 , and Risto A Kauppinen 1
1
School of Experimental Psychology and CRIC,
University of Bristol, Bristol, United Kingdom,
2
Department
of Neurobiology, University of Eastern Finland, Kuopio,
Finland
Thrombolytic therapy for acute ischaemic stroke requires
known symptom onset time, however for many patients this
is unknown. We determined time-dependent changes of T
1
and
T
2
in
ischaemic rat brain. Both T
1
and
T
2
relaxation
times increased linearly in the ischaemic lesion for the
observation time of 5 hours. T
1
and T
2
prolongation
occurred in different regions in early moments and
overlapped at later time-points. Volume of overlap
increased linearly with time, thus combining these
parameters provides a further proxy for stroke onset
time and assessment of tissue status. Quantitative
relaxometry bears potentials for acute stroke patient
stratification.
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