Abstract #2150
Absolute T 1 and T 2 Relaxation Times; Proxies for Onset Time and Tissue Status Assessment in Acute Ischaemic Stroke
Harriet J Rogers 1 , Bryony L McGarry 1 , Kimmo T Jokivarsi 2 , Michael J Knight 1 , Alejandra Sierra Lopez 2 , Olli HJ Grhn 2 , and Risto A Kauppinen 1
1
School of Experimental Psychology and CRIC,
University of Bristol, Bristol, United Kingdom,
2
Department
of Neurobiology, University of Eastern Finland, Kuopio,
Finland
Thrombolytic therapy for acute ischaemic stroke requires
known symptom onset time, however for many patients this
is unknown. We determined time-dependent changes of T
1
and
T
2
in
ischaemic rat brain. Both T
1
and
T
2
relaxation
times increased linearly in the ischaemic lesion for the
observation time of 5 hours. T
1
and T
2
prolongation
occurred in different regions in early moments and
overlapped at later time-points. Volume of overlap
increased linearly with time, thus combining these
parameters provides a further proxy for stroke onset
time and assessment of tissue status. Quantitative
relaxometry bears potentials for acute stroke patient
stratification.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
