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Abstract #2150

Absolute T 1 and T 2 Relaxation Times; Proxies for Onset Time and Tissue Status Assessment in Acute Ischaemic Stroke

Harriet J Rogers 1 , Bryony L McGarry 1 , Kimmo T Jokivarsi 2 , Michael J Knight 1 , Alejandra Sierra Lopez 2 , Olli HJ Grhn 2 , and Risto A Kauppinen 1

1 School of Experimental Psychology and CRIC, University of Bristol, Bristol, United Kingdom, 2 Department of Neurobiology, University of Eastern Finland, Kuopio, Finland

Thrombolytic therapy for acute ischaemic stroke requires known symptom onset time, however for many patients this is unknown. We determined time-dependent changes of T 1 and T 2 in ischaemic rat brain. Both T 1 and T 2 relaxation times increased linearly in the ischaemic lesion for the observation time of 5 hours. T 1 and T 2 prolongation occurred in different regions in early moments and overlapped at later time-points. Volume of overlap increased linearly with time, thus combining these parameters provides a further proxy for stroke onset time and assessment of tissue status. Quantitative relaxometry bears potentials for acute stroke patient stratification.

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