Meeting Banner
Abstract #2149

Monitoring Response to Neuregulin-1 in a Rat Model of Stroke Using Perfusion- and Diffusion Weighted MRI

Ramesh Paudyal 1 , Yonggang Li 2 , Silun Wang 1 , Byron D. Ford 2 , and Xiaodong Zhang 1

1 Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States, 2 Neurobiology, Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA, United States

Neuregulin-1 (NRG-1) has shown the neuroprotective effects in ischemic brain injury by reducing infarct volume and protecting neurons from ischemic damage. This study evaluates the neuroprotective effect of NRG-1 in a rat stroke model induced by permanent middle cerebral artery occlusion (pMCAo) using perfusion-and diffusion weighted magnetic resonance imaging (MRI) at 3hr and 48 hr and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and cresyl violet staining (CV) at 48 hr. Results showed that the vehicle treated group has a significantly greater ischemic lesion volume and mismatch region at 3hr than NRG-1 treated group. Our finding showed that NRG-1 served as a potent neuroprotectants in ischemic injury.

This abstract and the presentation materials are available to members only; a login is required.

Join Here