Abstract #2149
Monitoring Response to Neuregulin-1 in a Rat Model of Stroke Using Perfusion- and Diffusion Weighted MRI
Ramesh Paudyal 1 , Yonggang Li 2 , Silun Wang 1 , Byron D. Ford 2 , and Xiaodong Zhang 1
1
Yerkes Imaging Center, Yerkes National
Primate Research Center, Emory University, Atlanta, GA,
United States,
2
Neurobiology,
Neuroscience Institute, Morehouse School of Medicine,
Atlanta, GA, United States
Neuregulin-1 (NRG-1) has shown the neuroprotective
effects in ischemic brain injury by reducing infarct
volume and protecting neurons from ischemic damage. This
study evaluates the neuroprotective effect of NRG-1 in a
rat stroke model induced by permanent middle cerebral
artery occlusion (pMCAo) using perfusion-and diffusion
weighted magnetic resonance imaging (MRI) at 3hr and 48
hr and terminal deoxynucleotidyl transferase dUTP nick
end labeling (TUNEL) and cresyl violet staining (CV) at
48 hr. Results showed that the vehicle treated group has
a significantly greater ischemic lesion volume and
mismatch region at 3hr than NRG-1 treated group. Our
finding showed that NRG-1 served as a potent
neuroprotectants in ischemic injury.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
