Abstract #2152
Chronic methylene blue treatment decreases ischemic stroke volume and improves functional behavioral recovery
Pavel Rodriguez 1 , Jiang (John) Zhao 1,2 , and Timothy Q. Duong 1
1
Research Imaging Institute, The University
of Texas Health Science Center, San Antonio, Texas,
United States,
2
Department
of Anatomy and Embryology, Peking University Health
Science Center, Beijing, United States
We previously reported that a single-dose methylene blue
(MB), an energy-enhancing drug, given hyperacutely
reduced infarct volume in permanent and transient MCAO
in rats using MRI up to 2 days. This study investigated
the effect of chronic MB therapy on ischemic stroke
volume along with behavioral score correlations 28 days
after stroke. We administered MB at day 0, 2, 7, 14 and
obtained stroke volume and functional behavioral
measurements out to 28 days. We also used a new more
aggressive treatment paradigm that involves doubling MB
dose over permanent ischemia and after reperfusion. We
hypothesized that this new MB treatment paradigm is
safe, decreases final stroke volumes and functional
sensorimotor deficit.
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