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Abstract #2153

ADC correlates of CBF and Tissue PO2 in global cerebral ischemia

Yash Vardhan Tiwari 1,2 and Timothy Duong 1

1 Research Imaging Institute, UT Health Science Center, San Antonio, Texas, United States, 2 Biomedical Engineering, UT, San Antonio, Texas, United States

Apparent diffusion coefficient is a highly sensitive marker for ischemic insult, but lacks desired specificity in distinguishing salvageable versus non-salvageable tissue. There is an ever urgent need to define ADC threshold correlates of cerebral blood flow (CBF) and tissue deoxygenation in ischemia. This study incorporated simultaneous tPO2 measurement with interleaved perfusion and diffusion MRI at high temporal resolution to measure patterns of ADC changes in correlation to CBF and tPO2 response immediately following global cerebral ischemia.

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