Abstract #2153
ADC correlates of CBF and Tissue PO2 in global cerebral ischemia
Yash Vardhan Tiwari 1,2 and Timothy Duong 1
1
Research Imaging Institute, UT Health
Science Center, San Antonio, Texas, United States,
2
Biomedical
Engineering, UT, San Antonio, Texas, United States
Apparent diffusion coefficient is a highly sensitive
marker for ischemic insult, but lacks desired
specificity in distinguishing salvageable versus
non-salvageable tissue. There is an ever urgent need to
define ADC threshold correlates of cerebral blood flow
(CBF) and tissue deoxygenation in ischemia. This study
incorporated simultaneous tPO2 measurement with
interleaved perfusion and diffusion MRI at high temporal
resolution to measure patterns of ADC changes in
correlation to CBF and tPO2 response immediately
following global cerebral ischemia.
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