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Abstract #2154

Assessment of Experimental Stroke Lesion Size Using 1T Benchtop MRI

Jed Wingrove* 1 , Daniel Stcukey* 1 , Valerie Taylor 1 , Thomas Roberts 1 , Rajiv Ramasawmy 1 , Bernard Siow+ 1 , and Mark Lythgoe+ 1

1 Centre for Advanced Biomedical Imaging, Department of Medicine, University College London, London, United Kingdom

Small animal stroke research commonly uses histological analysis for the evaluation of pathological severity, however, histology precludes longitudinal studies of stroke evolution. Non-invasive, in vivo MRI has become increasingly prominent in pre-clinical settings, hugely benefiting the prediction of long-term pharmacological outcomes. However, most pre-clinical MRI systems operate at high field (≥ 4.7T), requiring cryogen cooling and are expensive to purchase and maintain. Recently, low-field (1T) benchtop MRI scanners have emerged which may be a cost-effective alternative. In this study, we demonstrate that a 1T benchtop MRI scanner is well suited to assessing stroke lesions in a rodent model of stroke.

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