Abstract #2154
Assessment of Experimental Stroke Lesion Size Using 1T Benchtop MRI
Jed Wingrove* 1 , Daniel Stcukey* 1 , Valerie Taylor 1 , Thomas Roberts 1 , Rajiv Ramasawmy 1 , Bernard Siow+ 1 , and Mark Lythgoe+ 1
1
Centre for Advanced Biomedical Imaging,
Department of Medicine, University College London,
London, United Kingdom
Small animal stroke research commonly uses histological
analysis for the evaluation of pathological severity,
however, histology precludes longitudinal studies of
stroke evolution. Non-invasive, in vivo MRI has become
increasingly prominent in pre-clinical settings, hugely
benefiting the prediction of long-term pharmacological
outcomes. However, most pre-clinical MRI systems operate
at high field (≥ 4.7T), requiring cryogen cooling and
are expensive to purchase and maintain. Recently,
low-field (1T) benchtop MRI scanners have emerged
which may be a cost-effective alternative. In this
study, we demonstrate that a 1T benchtop MRI scanner is
well suited to assessing stroke lesions in a rodent
model of stroke.
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