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Abstract #2155

Age Dependent Differences in Photothrombotic Ischemic Injury Detected Using Quantitative MR Imaging

Ursula Tuor 1 , Min Qiao 2 , Manasi Sule 2 , Qinbo Deng 2 , Melissa Morgunov 2 , David Rushforth 2 , and Tadeusz Foniok 2

1 Physiology and Pharmacology, Cl Neurosciences and Radiology, University of Calgary, Calgary, AB, Canada, 2 University of Calgary, Calgary, AB, Canada

We investigated whether differing severities of photothrombotic insults could be produced in immature brain as observed in adult rats previously. Mild lesions in neonatal cortex consisted of small hyperintense DW regions corresponding to marked increases in T2. In contrast, adults had hyperintense DW regions corresponding to marked T2 increases but also modest T2 increases beyond the DW lesion border. In contrast to neonatal brain, T2 is more sensitive for detecting ischemic injury than DW in adult brain. The results indicate a promising approach to study thrombotic occlusion and reperfusion injury and its MR diagnosis using quantitative T2, DW and ADC.

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