Meeting Banner
Abstract #2156

Cerebrovascular damage after stroke in type two diabetic rats measured by MRI

Guangliang Ding 1 , Tao Yan 1 , Jieli Chen 1 , Michael Chopp 1,2 , Lian Li 1 , Qingjiang Li 1 , Chengcheng Cui 1 , Ruizhuo Ning 1 , and Quan Jiang 1

1 Neurology, Henry Ford Hospital, Detroit, Michigan, United States, 2 Physics, Oakland University, Rochester, Michigan, United States

Using a suture 2h occlusion and reperfusion stroke model and a low dose Streptozotocin injection combined with a high fat food diet diabetic model of young adult Wistar rats, Gd-DTPA leakage measured by CE-T1WI indicates that T2DM rats suffered more severe BBB disruption from 1 to 5 weeks after stroke (p<0.005), and SWI identified significant larger hemorrhagic volumes in T2DM rats throughout 5w after stroke (p<0.05), compared with WT rats. FA values of ischemic boundary in the striatum were consistently lower in the T2DM rats than in the WT controls, which suggest that T2DM hampers axonal density increase.

This abstract and the presentation materials are available to members only; a login is required.

Join Here