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Abstract #2157

Development of a Porcine Middle Cerebral Artery Occlusion Stroke Model and Stroke Characterization with Quantitative MRI Techniques.

Shannon P. Holmes 1 , Simon R. Platt 2 , Liya Wang 3 , Vivian Lau 2 , Grace Harrison 2 , Hui Mao 3 , and Franklin West 2

1 Veterinary Biosciences & Diagnostic Imaging, University of Georgia, Athens, GA, United States, 2 University of Georgia, GA, United States, 3 Emory University, GA, United States

Large animal models of stroke are needed for improved translation of novel therapeutics. The pig has been proposed as ideal, because of similar gyrification, gray-white matter composition and size to the human brain. This study developed a Landrace pig middle cerebral artery occlusion (MCAO) model. Anatomic and quantitative MRI techniques were used to evaluate the stroke, including DWI, spectroscopy, DTI and PWI. Anatomic studies, with DWI/ADC, measured the penumbra and ischemic zone. Significant differences were detected in neural metabolites and fractional anistrophy of white matter. Therefore, the Landrace pig MCAO model is feasible and produces in vivo quantifiable changes.

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