Abstract #2158
Assessment of neuroprotective effects of Neuregulin-1 on in acute stroke using diffusion MRI
Silun Wang 1 , Yonggang Li 2 , Ramesh Paudyal 1 , Byron D. Ford 2 , and Xiaodong Zhang 1,3
1
YERKES IMAGING CENTER, Emory University,
Atlanta, GA, United States,
2
Department
of Neurobiology, Morehouse School of Medicine, GA,
United States,
3
Division
of Neuropharmacology and Neurologic Diseases, Emory
University, GA, United States
We evaluated the NRG-1 treatment response in a rat model
of ischemic stroke using DTI. Results indicated that
significantly lower infraction volume in the treatment
group than in control group. Especially, it is shown the
neuroprotective efficacy of NRG-1 is more evident in
stroke rats with mild CBF reduction (<70% reduction).
Significantly lower FA values were found in the vehicle
group compared to NRG-1 treatment group, indicating less
ischemic injury after NRG-1 administration. Our results
support the use of DTI as a biomarker to non-invasively
monitor the NRG-1 treatment response in ischemia induced
brain injury.
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