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Abstract #2158

Assessment of neuroprotective effects of Neuregulin-1 on in acute stroke using diffusion MRI

Silun Wang 1 , Yonggang Li 2 , Ramesh Paudyal 1 , Byron D. Ford 2 , and Xiaodong Zhang 1,3

1 YERKES IMAGING CENTER, Emory University, Atlanta, GA, United States, 2 Department of Neurobiology, Morehouse School of Medicine, GA, United States, 3 Division of Neuropharmacology and Neurologic Diseases, Emory University, GA, United States

We evaluated the NRG-1 treatment response in a rat model of ischemic stroke using DTI. Results indicated that significantly lower infraction volume in the treatment group than in control group. Especially, it is shown the neuroprotective efficacy of NRG-1 is more evident in stroke rats with mild CBF reduction (<70% reduction). Significantly lower FA values were found in the vehicle group compared to NRG-1 treatment group, indicating less ischemic injury after NRG-1 administration. Our results support the use of DTI as a biomarker to non-invasively monitor the NRG-1 treatment response in ischemia induced brain injury.

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