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Abstract #2159

Assessment of pharmacologically induced hypothermia in a rodent model of focal cerebral ischemia using diffusion tensor imaging

Silun Wang 1 , Xiaohuan Gu 2 , Ramesh Paudyal 1 , Shan Ping Yu 2 , and Xiaodong Zhang 1,3

1 YERKES IMAGING CENTER, Emory University, Atlanta, GA, United States, 2 Department of Anesthesiology and Department of Neurology, Emory University School of Medicine, GA, United States, 3 Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, GA, United States

We evaluated the pharmacologically induced hypothermia treatment response in focal cerebral ischemia induced brain injury in a mice model using DTI. Results indicated that significantly lower infraction volume in the treatment group than control group. Less reduction of ADC values were found in the hypothermia treatment group. Our results support the use of DTI as a biomarker to non-invasively monitor the hypothermia treatment response in ischemia induced brain injury.

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