Abstract #2161
Absolute and Relative Blood Volume Measurements by dual T1 and T2 MRI acquisitions with single contrast agent in Acute Phase of Ischemic Brain
Ji-Yeon Suh 1 , Hoesu Jung 2 , Hyung Joon Cho 2 , Young Ro Kim 3 , Jeong Kon Kim 4 , and Gyunggoo Cho 1
1
Magnetic Resonance Research, Korea Basic
Science Institute, Cheongju, Chungbuk, Korea,
2
Nano-Bioscience
and Chemical Engineering, Ulsan National Institute of
Science & Technology (UNIST), Ulsan, Korea,
3
Martinos
Center for Biomedical Imaging, Massachusetts General
Hospital, Massachusetts, United States,
4
Asan
Medical Center University of Ulsan college of Medicine,
Seoul, Korea
To study the altered cerebrovascular tones following
focal or global cerebral ischemia, infrequently
measuring changes in T2(*)-driven relative blood volumes
have been performed. In the current study, using the
concurrent T1-T2 effects of the exogenous contrast
agent, dual contrasts acquisitions were established in
the acute phase of rat ischemia model. Co-acquisitions
of positive (T1) and negative (T2(*)) contrasts provide
complementary information on neurovascular traits such
as absolute and relative cerebral blood volume and
microvascular volume. This work may supply an important
basis for understanding the impaired cerebrovascular
changes involved with ischemic damage.
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