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Abstract #2161

Absolute and Relative Blood Volume Measurements by dual T1 and T2 MRI acquisitions with single contrast agent in Acute Phase of Ischemic Brain

Ji-Yeon Suh 1 , Hoesu Jung 2 , Hyung Joon Cho 2 , Young Ro Kim 3 , Jeong Kon Kim 4 , and Gyunggoo Cho 1

1 Magnetic Resonance Research, Korea Basic Science Institute, Cheongju, Chungbuk, Korea, 2 Nano-Bioscience and Chemical Engineering, Ulsan National Institute of Science & Technology (UNIST), Ulsan, Korea, 3 Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Massachusetts, United States, 4 Asan Medical Center University of Ulsan college of Medicine, Seoul, Korea

To study the altered cerebrovascular tones following focal or global cerebral ischemia, infrequently measuring changes in T2(*)-driven relative blood volumes have been performed. In the current study, using the concurrent T1-T2 effects of the exogenous contrast agent, dual contrasts acquisitions were established in the acute phase of rat ischemia model. Co-acquisitions of positive (T1) and negative (T2(*)) contrasts provide complementary information on neurovascular traits such as absolute and relative cerebral blood volume and microvascular volume. This work may supply an important basis for understanding the impaired cerebrovascular changes involved with ischemic damage.

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