Abstract #2162
MRI of a distal MCAO ischemic stroke lesion model in mice
Tom Dresselaers 1 , Annelies Quaegebeur 2,3 , Kristof Govaerts 1 , Inmaculada Segura 2,3 , Robin Lemmens 4 , Peter Carmeliet 2,3 , and Uwe Himmelreich 1
1
Dept. of Imaging and Pathology, KU Leuven,
Leuven, Belgium,
2
Vesalius
Research Center, VIB, Belgium,
3
KU
Leuven, Leuven, Belgium,
4
VIB,
Belgium
In this study we characterized the stroke lesion in mice
resulting from a permanent distal MCAO. At 2, 24h and 1
week post occlusion quantitative perfusion data based on
pulsed ASL and ADC, T1 and T2 maps were recorded. Images
were analyzed using either manual delineation or a
threshold based approach with the contra-lateral cortex
as a reference region. We demonstrate that lesion
characterization via MRI in this distal MCAO mouse
stroke model is feasible thereby opening up the
possibility to non-invasively monitor stroke development
in different transgenic animal models related to for
example oxygen sensors or hypoxia.
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