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Abstract #2162

MRI of a distal MCAO ischemic stroke lesion model in mice

Tom Dresselaers 1 , Annelies Quaegebeur 2,3 , Kristof Govaerts 1 , Inmaculada Segura 2,3 , Robin Lemmens 4 , Peter Carmeliet 2,3 , and Uwe Himmelreich 1

1 Dept. of Imaging and Pathology, KU Leuven, Leuven, Belgium, 2 Vesalius Research Center, VIB, Belgium, 3 KU Leuven, Leuven, Belgium, 4 VIB, Belgium

In this study we characterized the stroke lesion in mice resulting from a permanent distal MCAO. At 2, 24h and 1 week post occlusion quantitative perfusion data based on pulsed ASL and ADC, T1 and T2 maps were recorded. Images were analyzed using either manual delineation or a threshold based approach with the contra-lateral cortex as a reference region. We demonstrate that lesion characterization via MRI in this distal MCAO mouse stroke model is feasible thereby opening up the possibility to non-invasively monitor stroke development in different transgenic animal models related to for example oxygen sensors or hypoxia.

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