Characterization of the ischemic penumbra using diffusion tensor MR imaging in a rat model of ischemic stroke treated with neuregulin-1
Silun Wang 1 , Yonggang Li 2 , Ramesh Paudyal 1 , Byron D. Ford 2 , and Xiaodong Zhang 1
YERKES IMAGING CENTER, Emory University,
Atlanta, GA, United States,
of Neurobiology, Morehouse School of Medicine, GA,
We have demonstrated that DTI indices could provide
promise diagnostic information to evaluate white matter
and grey matter injury in an rat model of ischemic
stroke treated by Neuregulin 1 as well as to
characterize the penumbra evolution after stroke onset.
The severity of white matter and cortex injury are
highly associated with the location of infarct and
vascular territory. In addition, the neuroprotective
effects could be in vivo monitored using DTI . NRG-1
seems to have significant neuroprotective effects to
white matter and cortex especially in acute stroke.
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