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Abstract #2163

Characterization of the ischemic penumbra using diffusion tensor MR imaging in a rat model of ischemic stroke treated with neuregulin-1

Silun Wang 1 , Yonggang Li 2 , Ramesh Paudyal 1 , Byron D. Ford 2 , and Xiaodong Zhang 1

1 YERKES IMAGING CENTER, Emory University, Atlanta, GA, United States, 2 Department of Neurobiology, Morehouse School of Medicine, GA, United States

We have demonstrated that DTI indices could provide promise diagnostic information to evaluate white matter and grey matter injury in an rat model of ischemic stroke treated by Neuregulin 1 as well as to characterize the penumbra evolution after stroke onset. The severity of white matter and cortex injury are highly associated with the location of infarct and vascular territory. In addition, the neuroprotective effects could be in vivo monitored using DTI . NRG-1 seems to have significant neuroprotective effects to white matter and cortex especially in acute stroke.

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