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Abstract #2166

Can diffusion weighted MR spectroscopy be used in differentiating acute MELAS and acute stroke?

Dandan Zheng 1 , Bing Wu 1 , Jiangxi Xiao 2 , Zhenghua Liu 2 , and Zhenyu Zhou 1

1 GE Healthcare China, Beijing, Beijing, China, 2 Radiology Department, Peking University First Hospital, Beijing, China

The underlying mechanism of neurological symptoms in patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) is still controversial. Signal abnormalities in conventional MR contrast are indistinguishable from those observed in stroke, especially in the acute stage. In this study, diffusion weighted MR spectroscopy was used to differentiate acute MELAS from acute stroke and also to probe the mechanisms underlying the pathogenesis of MELAS.

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