Prevalence of cerebrovascular reserve impairment in patients with severe intracranial arterial stenosis
Alexandre Krainik 1 , Olivier Heck 2 , Arnaud Atty 2 , Naila Boudiaf 3 , Florence Tahon 2 , Kamel Boubagra 2 , Johan Pietras 2 , and Olivier Detante 2
Neuroradiology and MRI, University hospital
of Grenoble, Grenoble, France,
hospital of Grenoble, France,
Management of patients with Severe Intracranial Arterial
Stenosis (SIAS) at risk of stroke events recurrence
remains controversial. A better characterization of
these patients might be helpful to define therapeutic
strategy. BOLD fMRI to hypercapnic challenge has been
proposed to identify impaired cerebrovascular reserve
(CVR BOLD fMRI). We conducted a prospective study in 35
patients referred for a SIAS to estimate CVR BOLD fMRI,
and compared their data a 100 volunteers dataset.
Eighteen patients out of 35 had significantly impaired
CVR. Thus, CVR BOLD fMRI could be helpful to better
select patients with SIAS for more invasive treatment.
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