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Abstract #2173

Prevalence of cerebrovascular reserve impairment in patients with severe intracranial arterial stenosis

Alexandre Krainik 1 , Olivier Heck 2 , Arnaud Atty 2 , Naila Boudiaf 3 , Florence Tahon 2 , Kamel Boubagra 2 , Johan Pietras 2 , and Olivier Detante 2

1 Neuroradiology and MRI, University hospital of Grenoble, Grenoble, France, 2 University hospital of Grenoble, France, 3 LPNC, France

Management of patients with Severe Intracranial Arterial Stenosis (SIAS) at risk of stroke events recurrence remains controversial. A better characterization of these patients might be helpful to define therapeutic strategy. BOLD fMRI to hypercapnic challenge has been proposed to identify impaired cerebrovascular reserve (CVR BOLD fMRI). We conducted a prospective study in 35 patients referred for a SIAS to estimate CVR BOLD fMRI, and compared their data a 100 volunteers dataset. Eighteen patients out of 35 had significantly impaired CVR. Thus, CVR BOLD fMRI could be helpful to better select patients with SIAS for more invasive treatment.

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