Abstract #2176
Quantifying the effects of lesions with the Tractography-based Lesion Assessment Standard (TractLAS)
Christopher J. Steele 1 , Leonie Lampe 1 , Alexander Schaefer 1,2 , Alfred Anwander 1 , Bernhard Sehm 1 , and Arno Villringer 1
1
Max Planck Institute for Human Cognitive and
Brain Sciences, Leipzig, Sachsen, Germany,
2
Department
of Electrical and Computer Engineering, Clinical Imaging
Research Centre & Singapore Insitu, Singapore,
Singapore, Singapore
Current MRI techniques for assessing the impact of brain
lesions consider only lesion location, type, and extent,
while ignoring how the lesioned region was previously
connected to the rest of the brain. To address this, we
created a tractography-based network model describing
normal white-matter connectivity in the human brain: the
TractLAS. Individual patient lesions can be introduced
into the model to quantify the effects of disconnection
on the network, and relate them to behaviour and
functional outcomes. This model helps to advance a
network-based understanding of the functional effects of
focal brain lesions.
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