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Abstract #2176

Quantifying the effects of lesions with the Tractography-based Lesion Assessment Standard (TractLAS)

Christopher J. Steele 1 , Leonie Lampe 1 , Alexander Schaefer 1,2 , Alfred Anwander 1 , Bernhard Sehm 1 , and Arno Villringer 1

1 Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Sachsen, Germany, 2 Department of Electrical and Computer Engineering, Clinical Imaging Research Centre & Singapore Insitu, Singapore, Singapore, Singapore

Current MRI techniques for assessing the impact of brain lesions consider only lesion location, type, and extent, while ignoring how the lesioned region was previously connected to the rest of the brain. To address this, we created a tractography-based network model describing normal white-matter connectivity in the human brain: the TractLAS. Individual patient lesions can be introduced into the model to quantify the effects of disconnection on the network, and relate them to behaviour and functional outcomes. This model helps to advance a network-based understanding of the functional effects of focal brain lesions.

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