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Abstract #2177

Identification of neurovascular changes in cerebral amyloid angiopathy by modeling subject-specific hemodynamic response functions

Rebecca J Williams 1,2 , Bradley Goodyear 1,2 , Stefano Peca 3 , Cheryl R McCreary 1,2 , Richard Frayne 1,2 , Eric E Smith 1,2 , and G Bruce Pike 1,2

1 Radiology and Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada, 2 Seaman Family MR Research Centre, Alberta Health Services, Calgary, Alberta, Canada, 3 Tom Baker Cancer Centre, University of Calgary, Calgary, Alberta, Canada

Cerebral amyloid angiopathy (CAA) is an age-related disease affecting the small blood vessels. Vascular changes resulting from CAA have been detected using fMRI, however modelling the hemodynamic response function (HRF) may provide further information than BOLD signal amplitude alone. Here we characterized the HRF in CAA patients and healthy controls. Subject-specific HRFs were estimated using the sum of two gamma functions model. The time-to-peak (TTP) and full-width at half-maximum (FWHM) of the positive response were calculated from each subject's HRF and quantitatively compared between groups. We found that the FWHM may be a sensitive marker of CAA-related neurovascular changes.

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