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Abstract #2181

Assessments of Oxygen Extraction Fraction in Canines with Internal Carotid Arteries Ligated on Both Sides

Peng Wu 1 , Feiyan Chang 2 , Sheng Xie 2 , and Hua Guo 1

1 Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, 2 Department of Radiology, ChinaJapan Friendship Hospital, Beijing, China

Measurements of oxygen extraction fraction are of great importance in the study of brain metabolism. There are several MRI-based methods, this study shows the feasibility of the model proposed by Haccke and Yablonskiy. Six canines with internal carotid arteries ligated on both sides were studied. The data were acquired with ASE-EPI sequence and used to estimate OEF by fitting to the model proposed by Haccke and Yablonskiy. The results showed that the OEF values of these canines increased significantly (p=0.004) after the ligation. DWI images and triphenyl tetrazolium chloride stained sections were consistent with the estimated OEF maps.

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