Abstract #2181
Assessments of Oxygen Extraction Fraction in Canines with Internal Carotid Arteries Ligated on Both Sides
Peng Wu 1 , Feiyan Chang 2 , Sheng Xie 2 , and Hua Guo 1
1
Center for Biomedical Imaging Research,
Department of Biomedical Engineering, School of
Medicine, Tsinghua University, Beijing, China,
2
Department
of Radiology, ChinaJapan Friendship Hospital, Beijing,
China
Measurements of oxygen extraction fraction are of great
importance in the study of brain metabolism. There are
several MRI-based methods, this study shows the
feasibility of the model proposed by Haccke and
Yablonskiy. Six canines with internal carotid arteries
ligated on both sides were studied. The data were
acquired with ASE-EPI sequence and used to estimate OEF
by fitting to the model proposed by Haccke and
Yablonskiy. The results showed that the OEF values of
these canines increased significantly (p=0.004) after
the ligation. DWI images and triphenyl tetrazolium
chloride stained sections were consistent with the
estimated OEF maps.
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