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Abstract #2198

Diffusion kurtosis imaging detects microstructural alterations in brain of α-synuclein overexpressing transgenic mouse model of Parkinsons disease: a pilot study

Peter Latta 1 , Amit Khairnar 1 , Eva Drazanova 2 , Jana Kucerova 1 , Anas Arab 1 , Birgit Hutter-Paier 3 , Daniel Havas 3 , Manfred Windisch 4 , Zenon Starcuk Jr. 2 , Boguslaw Tomanek 1,5 , and Irena Rektorova 1

1 Central European Institute of Technology, Masaryk University, Brno, Czech Republic, 2 Institute of Scientific Instruments, Academy of Sciences of the Czech Republic, Brno, Czech Republic, 3 QPS Austria GmbH, Graz, Austria, 4 NeuroScios GmbH, Graz, Austria, 5 University of Alberta, Edmonton, Alberta, Canada

Background: Accumulation and aggregation of α-synuclein contribute to the pathogenesis of Parkinsons disease (PD). Our aim was to evaluate whether diffusion kurtosis imaging (DKI) will help to differentiate between α-synuclein overexpressing transgenic mouse model of PD (TNWT-61) and wild-type (WT) littermates. Methods: TNWT-61 mice and WT littermates (9 month) underwent behavioral tests and MRI scanning using 9.4 Tesla system in vivo. Results: TNWT-61 mice showed significant motor impairment. Mean and radial diffusion kurtosis were significantly elevated in the TNWT-61 compared to WT Conclusions: The current study provides evidence that DKI might become a candidate diagnostic biomarker with translational potential.

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