Abstract #2198
Diffusion kurtosis imaging detects microstructural alterations in brain of α-synuclein overexpressing transgenic mouse model of Parkinsons disease: a pilot study
Peter Latta 1 , Amit Khairnar 1 , Eva Drazanova 2 , Jana Kucerova 1 , Anas Arab 1 , Birgit Hutter-Paier 3 , Daniel Havas 3 , Manfred Windisch 4 , Zenon Starcuk Jr. 2 , Boguslaw Tomanek 1,5 , and Irena Rektorova 1
1
Central European Institute of Technology,
Masaryk University, Brno, Czech Republic,
2
Institute
of Scientific Instruments, Academy of Sciences of the
Czech Republic, Brno, Czech Republic,
3
QPS
Austria GmbH, Graz, Austria,
4
NeuroScios
GmbH, Graz, Austria,
5
University
of Alberta, Edmonton, Alberta, Canada
Background: Accumulation and aggregation of α-synuclein
contribute to the pathogenesis of Parkinsons disease
(PD). Our aim was to evaluate whether diffusion kurtosis
imaging (DKI) will help to differentiate between
α-synuclein overexpressing transgenic mouse model of PD
(TNWT-61) and wild-type (WT) littermates. Methods:
TNWT-61 mice and WT littermates (9 month) underwent
behavioral tests and MRI scanning using 9.4 Tesla system
in vivo. Results: TNWT-61 mice showed significant motor
impairment. Mean and radial diffusion kurtosis were
significantly elevated in the TNWT-61 compared to WT
Conclusions: The current study provides evidence that
DKI might become a candidate diagnostic biomarker with
translational potential.
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