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Abstract #2199

Application of GluCEST MRI in Detection of Epileptogenic Foci in Temporal Lobe Epilepsy

Ravi Prakash Reddy Nanga 1 , Kathryn A. Davis 2 , Sandhitsu Das 3 , Stephanie H. Chen 2 , Peter Hadar 2 , Timothy H. Lucas 4 , Brian Litt 2 , John A. Detre 2 , Hari Hariharan 1 , Mark A. Elliott 1 , and Ravinder Reddy 1

1 Radiology, University of Pennsylvania Health Systems, Philadelphia, Pennsylvania, United States, 2 Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, United States, 3 Penn Image Computing & Science Lab, University of Pennsylvania, Philadelphia, Pennsylvania, United States, 4 Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, United States

Glutamate is widely thought to be central to epileptogenesis. Here we apply a novel noninvasive glutamate imaging technique, GluCEST (Glutamate Chemical Exchange Saturation Transfer) MRI at 7T with an aim to identify seizure foci with finer precision and higher sensitivity than currently used imaging modalities in subjects with Temporal Lobe Epilepsy (TLE).

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