Abstract #2202
Diffusion Changes in the Medulla Oblongata in Parkinson Disease
Nadya Pyatigorskaya 1,2 , Romain Valabregue 1,3 , Cyril Poupon 4 , Marie Vidailhet 3,5 , and Stephane Lehericy 1,2
1
Centre de NeuroImagerie de Recherche
CENIR, Institut du Cerveau et de la Moelle pinire
ICM, Paris, France,
2
Department
of Neuroradiology, Hpital Pitie-Salpetriere, Paris,
France,
3
Universit
Pierre et Marie Curie and Inserm UMR-S1127; CNRS, UMR
7225, Institut du Cerveau et de la Moelle pinire
ICM, Paris, France,
4
NeuroSpin,
CEA, Saclay, France,
5
Federation
de Neurologie, Hpital Pitie-Salpetriere, Paris, France
According to Braak's model, the medulla oblongata and
posterior pontine region may be affected early in the
course of Parkinson Disease. Therefore, the aim of the
present study was to characterize medulla oblongata
damage using diffusion tensor imaging (DTI) in PD
patients as compared with healthy volunteers. Increased
diffusivity was observed in both medulla oblongata and
pontine tegmentum. Longitudinal progression of diffusion
changes in the medulla oblongata of PD patients and
correlations with measures of autonomic dysfunction are
currently being investigated
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