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Abstract #2202

Diffusion Changes in the Medulla Oblongata in Parkinson Disease

Nadya Pyatigorskaya 1,2 , Romain Valabregue 1,3 , Cyril Poupon 4 , Marie Vidailhet 3,5 , and Stephane Lehericy 1,2

1 Centre de NeuroImagerie de Recherche CENIR, Institut du Cerveau et de la Moelle pinire ICM, Paris, France, 2 Department of Neuroradiology, Hpital Pitie-Salpetriere, Paris, France, 3 Universit Pierre et Marie Curie and Inserm UMR-S1127; CNRS, UMR 7225, Institut du Cerveau et de la Moelle pinire ICM, Paris, France, 4 NeuroSpin, CEA, Saclay, France, 5 Federation de Neurologie, Hpital Pitie-Salpetriere, Paris, France

According to Braak's model, the medulla oblongata and posterior pontine region may be affected early in the course of Parkinson Disease. Therefore, the aim of the present study was to characterize medulla oblongata damage using diffusion tensor imaging (DTI) in PD patients as compared with healthy volunteers. Increased diffusivity was observed in both medulla oblongata and pontine tegmentum. Longitudinal progression of diffusion changes in the medulla oblongata of PD patients and correlations with measures of autonomic dysfunction are currently being investigated

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