Abstract #2203
Odor-related Functional Deficits in the Primary Olfactory Cortex in Early-stage Parkinson's Disease
Jianli Wang 1 , Thyagarajan Subramanian 2,3 , Zachary Mosher 1 , Jeffrey Vesek 1 , and Qing X Yang 1,4
1
Radiology, Penn State College of Medicine,
Hershey, Pennsylvania, United States,
2
Neurology,
Penn State College of Medicine, Hershey, Pennsylvania,
United States,
3
Neural
& Behavioral Sciences, Penn State College of Medicine,
Hershey, Pennsylvania, United States,
4
Neurosurgery,
Penn State College of Medicine, Hershey, Pennsylvania,
United States
The central olfactory system is highly affected by PD
pathology and olfactory dysfunction is prevalent in
Parkinson's disease (PD). With a sniffing-odor
stimulation fMRI paradigm, we demonstrated significant
reduced odor-induced activation in the primary and
secondary olfactory cortex of early-stage PD patients
compared to the healthy controls. The observed POC
dysfunction was consistent with the impairment of smell
identification function detected by the psychophysical
test. Conversely, the sniffing function in the POC was
less affected at the early stage of disease. In
conclusion, olfactory deficits in the early-stage PD are
dominantly odor-related.
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