Abstract #2204
Abnormalities in the Visual System of Streptozotocin-induced Type 1 Diabetic Rats-A Diffusion Tensor Imaging Study
Lifeng Gao 1 , Mingming Huang 2 , Fuchun Lin 1 , and Hao Lei 1
1
State Key Laboratory of Magnetic Resonance
and Atomic and Molecular Physics, Wuhan Institute of
Physics and Mathematics, Chinese Academy of Sciences,
Wuhan, Hubei, China,
2
Department
of Radiology Affiliated Hospital of Guiyang Medical
University, Guiyang, Guizhou, China
Type 1 diabetes was induced in rats by a single
injection of streptozotocin (STZ). Diffusion tensor
imaging on the visual system were performed at 12 weeks
on a 7 T scanner to monitor the microstructure
abnormalities induced by diabetes. Fractional anisotropy
(FA), axial diffusivity (ADC
||
) and radial
diffusivity (ADC
) in the optic tracts and
visual cortex were measured. Compared to the control
animals, the STZ-treated rats showed significantly
reduced FA in both the optic tracts and visual cortex at
12 weeks after diabetes induction. Correspondingly,
significantly decreased ADC
||
and
significantly increased ADC
were
associated with hyperglycemia. The VC in the diabetic
rats had a slight decline in ADC
||
, and a
slight increase in ADC
relative
to those in controls.
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