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Abstract #2204

Abnormalities in the Visual System of Streptozotocin-induced Type 1 Diabetic Rats-A Diffusion Tensor Imaging Study

Lifeng Gao 1 , Mingming Huang 2 , Fuchun Lin 1 , and Hao Lei 1

1 State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, Hubei, China, 2 Department of Radiology Affiliated Hospital of Guiyang Medical University, Guiyang, Guizhou, China

Type 1 diabetes was induced in rats by a single injection of streptozotocin (STZ). Diffusion tensor imaging on the visual system were performed at 12 weeks on a 7 T scanner to monitor the microstructure abnormalities induced by diabetes. Fractional anisotropy (FA), axial diffusivity (ADC || ) and radial diffusivity (ADC ) in the optic tracts and visual cortex were measured. Compared to the control animals, the STZ-treated rats showed significantly reduced FA in both the optic tracts and visual cortex at 12 weeks after diabetes induction. Correspondingly, significantly decreased ADC || and significantly increased ADC were associated with hyperglycemia. The VC in the diabetic rats had a slight decline in ADC || , and a slight increase in ADC relative to those in controls.

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