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Abstract #2205

Diffusion MRI of the spinal cord allows in vivo early detection and monitoring of GM and WM degeneration in a murine ALS model

Ileana Zucca 1 , Matteo Figini 1 , Alessandro Scotti 1 , Stefania Marcuzzo 2 , Silvia Bonanno 2 , Victoria Moreno Manzano 3 , Jos Manuel Garcia Verdugo 4 , Pia Bernasconi 2 , Renato Mantegazza 2 , and Maria Grazia Bruzzone 5

1 Scientific Direction, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milan, Milan, Italy, 2 Neurology IV - Neuromuscular Diseases and Neuroimmunology Unit, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milan, Italy, 3 Neuronal and Tissue Regeneration laboratory, Centro de Investigacin Prncipe Felipe, Valencia, Spain, 4 Unidad de Neurobiologa comparada, Universidad de Valencia, Valencia, Spain, 5 Neuroradiology Unit, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milan, Italy

The aim of this work was to investigate the potential of in vivo DTI parameters to detect WM and GM degeneration in the G93A-SOD1 mouse model of Amyotrophic lateral sclerosis (ALS). 7 G93A-SOD1 mice and 7 WT-SOD1 mice were followed at multiple time points (9, 10, 12, 15 and 17 weeks of age) with a DTI protocol on a 7T MRI scanner. DTI parameters, in particular AD in WM and MD in GM, highlighted very early alterations especially in ventral regions, confirmed by histology and electron microscopy. DTI parameters may therefore be early in vivo biomarkers of neurodegeneration in ALS.

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