Abstract #2205
Diffusion MRI of the spinal cord allows in vivo early detection and monitoring of GM and WM degeneration in a murine ALS model
Ileana Zucca 1 , Matteo Figini 1 , Alessandro Scotti 1 , Stefania Marcuzzo 2 , Silvia Bonanno 2 , Victoria Moreno Manzano 3 , Jos Manuel Garcia Verdugo 4 , Pia Bernasconi 2 , Renato Mantegazza 2 , and Maria Grazia Bruzzone 5
1
Scientific Direction, Fondazione IRCCS
Istituto Neurologico "Carlo Besta", Milan, Milan, Italy,
2
Neurology
IV - Neuromuscular Diseases and Neuroimmunology Unit,
Fondazione IRCCS Istituto Neurologico "Carlo Besta",
Milan, Italy,
3
Neuronal
and Tissue Regeneration laboratory, Centro de
Investigacin Prncipe Felipe, Valencia, Spain,
4
Unidad
de Neurobiologa comparada, Universidad de Valencia,
Valencia, Spain,
5
Neuroradiology
Unit, Fondazione IRCCS Istituto Neurologico "Carlo
Besta", Milan, Italy
The aim of this work was to investigate the potential of
in vivo DTI parameters to detect WM and GM degeneration
in the G93A-SOD1 mouse model of Amyotrophic lateral
sclerosis (ALS). 7 G93A-SOD1 mice and 7 WT-SOD1 mice
were followed at multiple time points (9, 10, 12, 15 and
17 weeks of age) with a DTI protocol on a 7T MRI
scanner. DTI parameters, in particular AD in WM and MD
in GM, highlighted very early alterations especially in
ventral regions, confirmed by histology and electron
microscopy. DTI parameters may therefore be early in
vivo biomarkers of neurodegeneration in ALS.
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