Abstract #2208
Pathological Differences in Neuromyelitis Optica Reflected Differently by Two Myelin Water Imaging Techniques
Shannon Kolind 1 , Praveena Manogaran 1 , Irene Vavasour 2 , Bretta Russell-Schulz 2 , Katrina McMullen 1 , Jing Zhang 2 , Cornelia Laule 2,3 , Alexander MacKay 2,4 , Alexander Rauscher 2 , David Li 2 , and Anthony Traboulsee 1
1
Medicine, University of British Columbia,
Vancouver, BC, Canada,
2
Radiology,
University of British Columbia, Vancouver, BC, Canada,
3
Pathology
& Laboratory Medicine, University of British Columbia,
Vancouver, BC, Canada,
4
Physics
and Astronomy, University of British Columbia,
Vancouver, BC, Canada
Neuromyelitis optica (NMO), while similar to multiple
sclerosis (MS), has a different mechanism for
demyelination and primarily affects the optic nerve and
spinal cord. We measured myelin water fraction using a
multi-echo GRASE approach (MWF) as well as mcDESPOT (fM)
in the optic radiations and corticospinal tract
(hypothesized to be demyelinated due to NMOs primary
optic nerve and spinal cord involvement), and the corpus
callosum (hypothesized to be unaffected). MWF was
reduced in NMO optic radiations and corticospinal tract
but not corpus callosum. Contrary to MS findings, fM was
not reduced in any region. This finding highlights how
differences in pathology are reflected by each approach.
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