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Abstract #2207

Microstructural Changes of Short Association Fibers in Parkinson's Disease and Normal Aging Assessed by Diffusion Tensor Imaging.

Jan Sedlacik 1 , Jan-Rdiger Schre 1,2 , Kai Boelmans 3 , and Jens Fiehler 1

1 University Medical Center Hamburg-Eppendorf, Hamburg, Hamburg, Germany, 2 Technical University of Ilmenau, Thringen, Germany, 3 University Hospital of Wrzburg, Bayern, Germany

Frontal and central short association fibers (U-fibers) were investigated by Diffusion Tensor Imaging (DTI) in Parkinson's disease (PD) and healthy subjects. Healthy age-related DTI changes were found in control subjects. In detail, axial (AD), radial (RD) and mean diffusivity (MD) increased in frontal and central fibers and fractional anisotropy (FA) decreased in frontal but increased in central fibers. Age matched healthy controls showed slightly lower AD/RD/MD and higher FA as compared to PD patients, which may suggest only a marginal microstructural degeneration of U-fibers in PD patients.

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