Comparative study of anatomical connectivity of prelemniscal radiations in healthy subjects and Parkinsons disease patients

Synopsis: Prelemniscal radiations (Raprl) are an exquisite neurosurgical target for treatment of tremor and rigidity. Despite its clinical relevance nowadays it remains unknown the anatomical connectivity of this area. Using diffusion MRI and probabilistic tractography we reconstructed different pathways passing trough the Raprl in healthy subjects and Parkinsons disease patients. We compared the number of streamlines of both groups. Raprl tractography showed connections with motor and premotor cortex, globus pallidus (GP), thalamus, cerebellum and brainstem, having statistical differences between groups in tracts associated to GP and thalamus. Our findings provide new insights into subthalamic anatomic connectivity useful for neurosurgical procedures.

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