Meeting Banner
Abstract #2211

High resolution MR elastography reveals retrograde thalamic tissue degradation in Neuromyelitis optica

Kaspar-Josche Streitberger 1,2 , Andreas Fehlner 1 , Friedemann Paul 3,4 , Jens Wrfel 3,5 , Jing Guo 1 , Jrgen Braun 6 , and Ingolf Sack 1

1 Department of Radiology, Charit - Universittsmedizin Berlin, Berlin, Germany, 2 Department of Neurology with experimental Neurology, Charit - Universittsmedizin Berlin, Berlin, Germany, 3 NeuroCure Clinical Research Center, Charit - Universittsmedizin Berlin, Berlin, Germany, 4 Clinical and Experimental Multiple Sclerosis Research Center, Department of Neurology, Charit - Universittsmedizin Berlin, Berlin, Germany, 5 Institute of Neuroradiology, Universittsmedizin Gttingen, Gttingen, Germany, 6 Institute of Medical Informatics, Charit - Universittsmedizin Berlin, Berlin, Germany

High resolution multifrequency MR elastography was applied to patients with Neuromyelitis optica (NMO) a disease which is characterized by recurrent inflammation and demyelination of the spinal cord and the optical nerves. Our hypothesis was based on reports on the sensitivity of viscoelastic parameters to neuroinflammation and neurodegradation. Consistently, high-resolution maps of the magnitude of the complex shear modulus revealed disseminated softening of cerebral tissue with marked effects on thalamus and white matter. The present study supports the hypothesis of a widespread cerebral neurodegeneraration in NMO and provides further details about regional effects of the disease.

This abstract and the presentation materials are available to members only; a login is required.

Join Here