Abstract #2211
High resolution MR elastography reveals retrograde thalamic tissue degradation in Neuromyelitis optica
Kaspar-Josche Streitberger 1,2 , Andreas Fehlner 1 , Friedemann Paul 3,4 , Jens Wrfel 3,5 , Jing Guo 1 , Jrgen Braun 6 , and Ingolf Sack 1
1
Department of Radiology, Charit -
Universittsmedizin Berlin, Berlin, Germany,
2
Department
of Neurology with experimental Neurology, Charit -
Universittsmedizin Berlin, Berlin, Germany,
3
NeuroCure
Clinical Research Center, Charit - Universittsmedizin
Berlin, Berlin, Germany,
4
Clinical
and Experimental Multiple Sclerosis Research Center,
Department of Neurology, Charit - Universittsmedizin
Berlin, Berlin, Germany,
5
Institute
of Neuroradiology, Universittsmedizin Gttingen,
Gttingen, Germany,
6
Institute
of Medical Informatics, Charit - Universittsmedizin
Berlin, Berlin, Germany
High resolution multifrequency MR elastography was
applied to patients with Neuromyelitis optica (NMO) a
disease which is characterized by recurrent inflammation
and demyelination of the spinal cord and the optical
nerves. Our hypothesis was based on reports on the
sensitivity of viscoelastic parameters to
neuroinflammation and neurodegradation. Consistently,
high-resolution maps of the magnitude of the complex
shear modulus revealed disseminated softening of
cerebral tissue with marked effects on thalamus and
white matter. The present study supports the hypothesis
of a widespread cerebral neurodegeneraration in NMO and
provides further details about regional effects of the
disease.
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