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Abstract #2213

Decreased Apparent Fibre Density in the optic pathways correlates with Glaucoma disease severity

David Raffelt 1 , Farnoosh Sadeghian 1 , Heather Connor 2 , and Alan Connelly 1,3

1 Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia, 2 Department of Optometry, Deakin University, Melbourne, VIC, Australia, 3 The Florey Department of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia

Glaucoma is the second leading cause of blindness worldwide with 8.4 million bilaterally blind people. White matter abnormalities have been reported previously in Glaucoma using the diffusion tensor, however these results are difficult to interpret in regions with crossing fibres. In this study we investigate Glaucoma disease using Apparent Fibre Density (AFD), a quantitative measure that is tract specific, even in voxels with multiple fibres. When compared to healthy controls, we observed a decrease in AFD in the optic tract and radiation. Within these tracts we also observed significant AFD correlations with clinical measures of disease severity.

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