Decreased Apparent Fibre Density in the optic pathways correlates with Glaucoma disease severity
David Raffelt 1 , Farnoosh Sadeghian 1 , Heather Connor 2 , and Alan Connelly 1,3
Florey Institute of Neuroscience and Mental
Health, Melbourne, VIC, Australia,
of Optometry, Deakin University, Melbourne, VIC,
Florey Department of Neuroscience and Mental Health,
University of Melbourne, Melbourne, VIC, Australia
Glaucoma is the second leading cause of blindness
worldwide with 8.4 million bilaterally blind people.
White matter abnormalities have been reported previously
in Glaucoma using the diffusion tensor, however these
results are difficult to interpret in regions with
crossing fibres. In this study we investigate Glaucoma
disease using Apparent Fibre Density (AFD), a
quantitative measure that is tract specific, even in
voxels with multiple fibres. When compared to healthy
controls, we observed a decrease in AFD in the optic
tract and radiation. Within these tracts we also
observed significant AFD correlations with clinical
measures of disease severity.
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