Abstract #2214
Whole-Brain Metabolic Profiling of Patients with Parkinson's Disease Using High-Resolution MR Spectroscopic Imaging
Mohammad Sabati, PhD 1 and Sasha Raju, MBBS 2
1
Radiology, University of Miami, Miami,
Florida, United States,
2
Public
Health Program, University of Miami, Miami, Florida,
United States
Metabolite concentrations in 47 atlas-defined brain
structures of 12 PD patients and 24 age- and
gender-matched normal subjects were measured by using a
sub-milliliter high-resolution whole-brain MR
spectroscopic imaging (MRSI). The distributions as well
as the statistically significant alterations of the
measured metabolites NAA, Cho, and Cre were regional
dependent. The results also indicate that the severity
of PD, as measured by motor score, is correlated with
the NAA and Cho/NAA in a number of the atlas-defined
regions.
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