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Abstract #2214

Whole-Brain Metabolic Profiling of Patients with Parkinson's Disease Using High-Resolution MR Spectroscopic Imaging

Mohammad Sabati, PhD 1 and Sasha Raju, MBBS 2

1 Radiology, University of Miami, Miami, Florida, United States, 2 Public Health Program, University of Miami, Miami, Florida, United States

Metabolite concentrations in 47 atlas-defined brain structures of 12 PD patients and 24 age- and gender-matched normal subjects were measured by using a sub-milliliter high-resolution whole-brain MR spectroscopic imaging (MRSI). The distributions as well as the statistically significant alterations of the measured metabolites NAA, Cho, and Cre were regional dependent. The results also indicate that the severity of PD, as measured by motor score, is correlated with the NAA and Cho/NAA in a number of the atlas-defined regions.

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