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Abstract #2215

Gadolinium-enhanced magnetic susceptibility contrast is reduced in the corpus callosum of a mouse model of Tauopathy

James O'Callaghan 1 , Holly Holmes 1 , Nicholas Powell 1 , Ozama Ismail 1 , Niall Colgan 1 , Jack Wells 1 , Bernard Siow 1 , Michael O'Neill 2 , Emily Collins 3 , Karin Shmueli 4 , and Mark Lythgoe 1

1 Centre for Advanced Biomedical Imaging, University College London, London, Greater London, United Kingdom, 2 Eli Lilly & Co. Ltd, Windlesham, Surrey, United Kingdom, 3 Eli Lilly and Company, Indianapolis, United States, 4 Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom

Alterations to white matter have been implicated in a number of neurodegenerative diseases. In this work we investigate the sensitivity of MRI magnetic susceptibility mapping to these changes using a mouse model of Tauopathy. A non-rigid registration of contrast enhanced, high resolution ex vivo mouse brain images is used to transform susceptibility maps into a common space and a voxel-wise group comparison is performed. Significant differences were observed that may indicate disruption to the tissue of the corpus callosum.

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