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Abstract #2216

Quantitative magnetization transfer characteristics of white matter tracts correlates with DTI indices in predicting the conversion from mild cognitive impairment to Alzheimers disease

Elena Makovac 1 , Barbara Spano' 1 , Giovanni Giulietti 1 , Laura Serra 1 , Carlo Caltagirone 2,3 , Marco Bozzali 1 , and Mara Cercignani 1,4

1 Neuroimaging laboratory, IRCCS Santa Lucia Foundation, Roma, Italy, Italy, 2 Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Roma, Italy, Italy, 3 Department of Neuroscience, University of Rome Tor Vergata, Roma, Italy, Italy, 4 Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, Brighton, Sussex, United Kingdom

Patients with amnestic mild cognitive impairment (aMCI) have a higher risk of conversion to AD than healthy elderly subjects. We used probabilistic tractography to perform a multiparametric comparison of diffusion tensor imaging (DTI) and quantitative magnetization transfer (qMT) indices of the principal WM tracts involved by AD pathology between aMCI converting to AD and those who did not. Subtle changes in brain structure associated were more evident in aMCI converters than MCI non converters. RMB0 values correlated with of RDif of in almost all tracts suggesting that the two parameters might reflect similar properties of WM.

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